Grapefruit seed extract cyst buster more from pubmed
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Author:  Cog1st [ Thu May 15, 2008 12:17 pm ]
Post subject:  Grapefruit seed extract cyst buster more from pubmed

There is quite a bit of talk about Grapefruit seed extract being a cyst good as flagyl and without toxic side effects of Flagyl.

Just thought I'd let you know so you can discuss w/your LLMD's.

MUCH more info in the Abstracts from pubmed of value re: cystic form/grapefruit seed extract - scroll down to my next post!

Author:  istherehope [ Fri May 16, 2008 8:37 am ]
Post subject:  Re: Grapefruit see extract cyst buster

interesting. although I have read on many abx and other meds things that it interferes with drugs. so for a natural protocol that might be wonderful...I wonder if the extract is still the same effect as an actual grapefruit or juice

Author:  Cog1st [ Fri May 16, 2008 9:38 am ]
Post subject:  Re: Grapefruit seed extract cyst buster

Good question - I don't think so, but If I remember this would be a question for Dr. B. I seriously need to do something like Flagyl, but would like to avoid it because of the neuropathy I've had it could make it much worse.

There are studies/abstracts on - this is one - it is AMAZING:

Grapefruit Seed Extract is a Powerful In Vitro Agent Against Motile and Cystic Forms of Borrelia
burgdorferi Sensu Lato

Infection. 2007 Jun;35(3):206-8. Brorson O, Brorson SH.

Lyme borreliosis [1], caused by B. burgdorferi sensu lato, may lead to long-term tissue infection, which may be difficult to cure. The outcome of Lyme borreliosis is highly dependant on the antibiotic treatment [2]. The observation of the ability of B. burgdorferi sensu lato to convert (and reconvert) to cystic forms [3–5] may explain why the infection sometimes is persistent and reactivating.

Therefore, it might be important to eradicate all germative forms (not only the motile form) of the bacterium to obtain a proper treatment for Lyme borreliosis. Grapefruit-seed extract (GSE) contains bioactive flavenoids (e.g., hesperitin, resveratrol, and naringenin) and has been shown to possess anti-microbiological effect against bacteria and fungus [6,7]. Many studies indicate that GSE is a substance whose therapeutic effect ranks equal to or better than other
known anti-bacterial agents.

Conclusion: The highest GSE concentrations made the bacteria and cysts disappear completely, leaving only small uncharacteristic fragments; at lower GSE-levels the membranes showed herniation and disruption, and the contents had leaked out. The MBC was strongly dependent on the length of the incubation. GSE was very active even for very short incubation times, in agreement with previous results [7].

The MBC obtained by DFM for the motile bacteria agreed well with the TEM results. Presence of GSE reduced the conversion from spirochetes to cysts when the susceptibility testing was performed in distilled water.

This study was performed in vitro and further studies are needed to demonstrate eventual effects in vivo. From our results it will be rational to test the hypothesis that a combination of GSE and antibiotics will be efficient in the treatment of resistant Lyme borreliosis.

Author:  Cog1st [ Fri May 16, 2008 12:17 pm ]
Post subject:  Re: Grapefruit seed extract cyst buster (better than Flagyl)

Here is a pubmed article saying macrolides w/tinidazole (related to Flagyl supposedly not as toxic as Flagyl) may kill cystic and mobile Bb forms : ... d_RVDocSum

The susceptibility of mobile and cystic forms of Borrelia burgdorferi to tinidazole (TZ) was examined. The minimal bactericidal concentration (MBC) of TZ against the mobile spirochetes was >128 microg/ml at 37 degrees C in micro-oxic atmosphere when incubated for 14 days. TZ significantly reduced the conversion of mobile spirochetes to cystic forms during incubation. The MBC for older (10-months-old) cysts at 37 degrees C in a micro-oxic atmosphere was >0.5 microg/ml, but >0.125 microg/ml for young (1-day-old) cysts. Acridine orange staining, dark-field microscopy and transmission electron microscopy revealed that, when the concentration of TZ was > or = MBC, the contents of the cysts were partly degraded, core structures did not develop inside the young cysts, and the amount of RNA in these cysts decreased significantly. When cysts were exposed to TZ, both the spirochetal structures and core structures inside the cysts dissolved, and the production of blebs was significantly reduced. These observations may be valuable in the treatment of resistant infections caused by B. burgdorferi, and suggest that a combination of TZ and a macrolide antibiotic could eradicate both cystic and mobile forms of B. burgdorferi.

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