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 Post subject: something showing promise in lyme treatment
PostPosted: Fri Jun 12, 2009 9:58 am 
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Medical news Today 10th June 2009
DNA Binding Compound That Kills Bacteria In 2 Minutes Could Lead To New Antibiotics

Main Category: Infectious Diseases / Bacteria / Viruses

Also Included In: Genetics; MRSA / Drug Resistance

Article Date: 10 Jun 2009 - 0:00 PDT



A synthetic DNA binding compound has proved surprisingly effective at binding to the DNA of bacteria and killing all the bacteria it touched within two minutes.

The DNA binding properties of the compound were first discovered in the Department of Chemistry at the University of Warwick by Professor Mike Hannon and Professor Alison Rodger (Professor Mike Hannon is now at the University of Birmingham).

However the strength of its antibiotic powers have now made it a compound of high interest for University of Warwick researchers working on the development of novel antibiotics.

Dr Adair Richards from the University of Warwick said: "This research will assist the design of new compounds that can attack bacteria in a highly effective way which gets around the methods bacteria have developed to resist our current antibacterial drugs.

As this antibiotic compound operates by targeting DNA, it should avoid all current resistance mechanisms of multi-resistant bacteria such as MRSA."


The compound [Fe2L3]4+ is an iron triple helicate with three organic strands wrapped around two iron centres to give a helix which looks cylindrical in shape and neatly fits within the major groove of a DNA helix.

It is about the same size as the parts of a protein that recognise and bind with particular sequences of DNA. The high positive charge of the compound enhances its ability to bind to DNA which is negatively charged.


When the iron-helicate binds to the major groove of DNA it coils the DNA so that it is no longer available to bind to anything else and is not able to drive biological or chemical processes.

Initially the researchers focused on the application of this useful property for targeting the DNA of cancer cells as it could bind to, coil up and shut down the cancer cell's DNA either killing the cell or stopping it replicate.

However the team quickly realised that it might also be a very clever way of targeting drug-resistant bacteria.


New research at the University of Warwick, led by Dr Adair Richards and Dr Albert Bolhuis, has now found that the [Fe2L3]4+ does indeed have a powerful effect on bacteria.

When introduced to two test bacteria Bacillus subtilis and E. coli they found that it quickly bound to the bacteria's DNA and killed virtually every cell within two minutes of being introduced - though the concentration required for this is high.


Professor Alison Rodger, Professor of Biophysical Chemistry at the University of Warwick, said:

"We were surprised at how quickly this compound killed bacteria and these results make this compound a key lead compound for researchers working on the development of novel antibiotics to target drug resistant bacteria."


The researchers will next try and understand how and why the compound can cross the bacteria cell wall and membranes.

They plan to test a wide range of compounds to look for relatives of the iron helicate that have the same mechanism for action in collaboration with researchers around the world.

Professor Mike Hannon from the University of Birmingham said:

"This research is a great example of how the Universities of Birmingham and Warwick are working together to deliver exciting new research that can impact on medicine and healthcare -

key themes of the AWM "Birmingham Science City" initiative which seeks to make the West Midlands the leading player in science and technology in the UK."


The research has just been published in the International Journal of Antimicrobial Agents in a paper entitled Antimicrobial activity of an iron triple helicate by Dr Adair D. Richards, and Professor Alison Rodger from the University of Warwick, Professor Michael J. Hannon from the University of Birmingham and Dr Albert Bolhuis from Bath University.

Issue 33 pp469-472

http://www.ijaaonline.com/article/S0924-8579(08)00577-3


Sandi Lanford, Founder/President
The Lanford Foundation - Lifelyme, Inc.
Tallahassee, FL
www.lifelyme.org

Disclaimer:
The mission of "THE LANFORD FOUNDATION - LIFELYME, INC., is to provide educational information for anyone interested in tick-borne diseases, chronic infectious, systemic diseases and related disorders. Information presented is intended only for educational exchange. This information is not offered by LIFELYME as medical advice for anyone.

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"something good WILL happen to me today"

(Isaiah 53:5 NKJV) But He was wounded for our transgressions, He was bruised for our iniquities; The chastisement for our peace was upon Him, And by His stripes we are healed.


Any advice given by me, is just that, advice. I am not a medical doctor, and I suggest you talk to your doctor about any concerns.


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 Post subject: Re: something showing promise in lyme treatment
PostPosted: Fri Jun 12, 2009 10:13 am 
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My first thought was - sounds scary! This abx sounds so strong, a herx generated by it makes me wonder if it could be deadly.

Can you imagine taking an abx and in 2 minutes be herxing?

I hope they find an easy cure for Lyme, all the pain and suffering involved in getting well is unbelievable.

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 Post subject: Re: something showing promise in lyme treatment
PostPosted: Fri Jun 12, 2009 12:15 pm 
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I was treated with 3 IVs back in November 2007 made up of the antimicrobials Bismacine, Sulfoxime and Dioxychlor. Sadly these substances are considered "unauthorized" by both our and the Canadian government. However, they are COMPLETELY safe, much less harmful than antibiotics (since abx kill off pretty much EVERYTHING in our bodies) and, including myself, have cured hundreds of Lyme (my doctor's office alone can attest to that - I have met many patients who went through the same treatment who are 100% cured and living healthy lives). Do you see why governments would immediately try to ban this treatment? Because it is FAST and it is a CURE. Treating Lyme with antibiotics means paying big bucks to pharmaceutical companies over a long period of time.

Needless to say the treatment does not take away from the truth that it was Jesus Christ who healed me, I do give all glory to Him. :cross:

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 Post subject: Re: something showing promise in lyme treatment
PostPosted: Sat Jun 13, 2009 6:08 am 
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My 1st thought was GIMME SOME!!!!!!! I want it.

Then I read Dana's post and was like well......Ya that could be a terrible Herx that could kill.

Then I read syme654's post and was more hopeful.

I would like to be a Ginnie pig for this drug. But as we all know the Government will NEVER let it out. If it can kill Cancer cells like that in minutes, then where would the $$$$$$$ be in the TREATMENT. It's all about $$$$$ for us and all people suffering with some sort of horrible Disease.

Well I will be hopeful and Optimistic that this drug will hit the Pharmacies in years to come.

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 Post subject: Re: something showing promise in lyme treatment
PostPosted: Mon Jun 15, 2009 5:27 am 
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well it might be all about money in our country, but in my world it's all about God! forget what any gov't official, especially the FDA has to say, as far as I"m concerned I"m more prone to buy non FDA approved stuff, lol... in the end it's in God's hands anyhow...I was up last night again, and prayed and prayed, told Him I accept my healing , I know he's using me for bigger things and it will be in His timing, and I feel like I have no right to complain, and thanked Him for all that I have, I know it could be worse.

_________________
"something good WILL happen to me today"

(Isaiah 53:5 NKJV) But He was wounded for our transgressions, He was bruised for our iniquities; The chastisement for our peace was upon Him, And by His stripes we are healed.


Any advice given by me, is just that, advice. I am not a medical doctor, and I suggest you talk to your doctor about any concerns.


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